base substitution sentence in Hindi
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- Thus 5-BrU induces a point mutation via base substitution.
- Different base substitutions or amino acid substitutions can have different scores.
- It causes DNA damage through base substitution and increases the number of mutations.
- However, MutS? does not repair base substitutions.
- The MutS? pathway is involved primarily in base substitution and small-loop mismatch repair.
- The enzyme recognizes all base substitutions and insertions / deletions, and cleaves the 32 side of mismatched sites in both DNA strands with high specificity
- Silent mutations are base substitutions that result in no change of the amino acid or amino acid functionality when the altered messenger RNA ( mRNA ) is translated.
- Using an equation derived by Smith and Eyre-Walker, we can estimate the proportion of base substitutions fixed by natural selection, ?, using the following formula:
- "' Denaturing High Performance Liquid Chromatography "'( DHPLC ) is a method of chromatography for the detection of base substitutions, small deletions or insertions at the DNA.
- Note, however, the absolute rate of indels in most known genomes, including humans, tends to be markedly lower than base substitutions, except near highly repetitive regions, including microsatellites.
- One of the commonly used enzymes is Surveyor nuclease ( CEL II ), which cleaves the 32 side of both DNA strands with high specificity at sites of base substitution or insertion / deletion.
- Additional difficulties include base substitutions ( especially at the 3 end of reads ) by inaccurate polymerases, chimeric sequences, and PCR-bias, all of which can contribute to generating an incorrect sequence.
- Gene mutations are commonly point mutations, altering only one base within the genetic sequence to alter the ensuing transcript and amino acid sequence; these point mutations include base substitutions, deletions, frame-shifts, and rearrangements.
- Most of the mutations observed ( 65 / 78 ) are single base substitutions or SNPs, 11 deletions, 1 large and 10 small, and 2 insertions . 8 of the observed mutations are frameshift, 6 deletions and 2 insertions.
- At the gene level, the mutations were found to cause primarily single-base substitution mutations, which suggests that the role of hMSH6 is primarily for correcting single-base substitution mutations and to a lesser extent single base insertion / deletion mutations.
- At the gene level, the mutations were found to cause primarily single-base substitution mutations, which suggests that the role of hMSH6 is primarily for correcting single-base substitution mutations and to a lesser extent single base insertion / deletion mutations.
- Until now, all the reported causal mutations in MLPH ( melanophilin ) of humans, mice and other species have been single-base substitutions or small deletions, the effects of which were limited to the dilution of hair or feather colour . cats, dogs and minks
- Misexpression in the developing eye has been found to result in overgrowth, partially through single base substitution which blocks the gain-of-function phenotype, indicating the acquisition of novel functions by misexpressed miRNAs which bring about unscheduled cell proliferation " in vivo ".
- In aerobically growing bacteria, ROS appear to be a major source of DNA damage, as indicated by the observation that 89 % of spontaneously occurring base substitution mutations are caused by introduction of ROS-induced single-strand damages followed by error-prone replication past these damages.
- Several statistical methods exist to extract from a multiple sequence alignment such coupled residue pairs : observed versus expected frequencies of residue pairs ( OMES ); the McLachlan Based Substitution correlation ( McBASC ); statistical coupling analysis; Mutual Information ( MI ) based methods; and, most recently, direct coupling analysis ( DCA)
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